Post-Stroke Improvements in Pain, Sensation, & Balance after treatment by Edward Tobinick, M.D.

About This Video

A patient returns for a one-week follow-up evaluation after receiving his first Perispinal Etanercept (PSE) treatment, sharing his personal observations alongside feedback from his family.

The video documents reported changes in localized pain levels, sleeping comfort, arm mobility, gait confidence, and fine motor control five years following his stroke.

Patient-Reported Changes Featured in This Video

  • Stroke Pain Relief & Sleep Quality: The patient reports a substantial reduction in shoulder pain immediately following the treatment, noting that he no longer required morning pain medication and could lie flat in bed to sleep through the night without elevating his shoulder.
  • Reduction in Spasticity & Tremors: The patient demonstrates improved control over his arm and hand, noting a decrease in tremors and spasticity. He highlights being able to safely touch his own face with his affected hand for the first time in five years.
  • Arm Mobility & Range of Motion: The patient reports being able to extend his arm outward to the side and move it up and down without discomfort.
  • Gait Confidence & Endurance: Both the patient and his parent describe an increase in physical stamina, noting that he successfully walked the full length of a pier and back—an activity he was previously unable to complete due to fatigue and fear of tripping.
  • Facial Tension & Cognitive Clarity: Family members observed a visible reduction in facial tension immediately after the procedure, while the patient reports feeling less drained upon waking and experiencing less “brain fog.”
Read Video Transcript

*Transcript generated by YouTube

So, you’re back here 1 week later, and what happened after your shot? Uh the pain immediately went down tremendously, and uh and it’s gone down more and more every day. I I’m pretty much completely pain-free. You know, I don’t have to get up in the morning very first thing and take a pain med. For the past 5 years, the only way I could sleep was to duck duck up this shoulder up cuz I I couldn’t straighten it out. Now I can straighten it out, lay in bed like a normal person. Now, I I’ve slept all night since the first shot a week ago. To wake up and get out of bed and not feel drained already. It’s amazing. And I can, you know, move my arm up and down, but that, you know, movement don’t don’t hurt it now. I used to never be able to put it out to the side like I’m flying or something. I got a lot more joy looking forward to stuff, you know. I can’t believe the results out of this, you know. [snorts] But the brain fog gets it’s getting better every day, you know. You know, I I used to just constantly look at the ground when I was walking cuz I’d trip over a a toothpick. Just things like that. You know, now I I can look ahead and see the scenery and, you know, more more. Yeah, I don’t have to concentrate on you know. What were the differences that you saw in your son after the shot? Oh, right away the the tension off his from his face was so much less. It’s just good to see him be able to walk around. We We took a walk last night. Something he we couldn’t do before. We went to the pier. He walked all the way down and all the way back. Couldn’t do that before. Oh, oh, no.

My arm would shake really bad coming back down. The spasticity and there’s hardly none right now. I had to punch myself in the face before I’d done this before. I can actually feel my face with my hand. Wow. I would never attempt that before. I’d have ended up poking my eye out or something.

That’s the first time I’ve touched my face in 5 years. I’m all right here.

I couldn’t do that

after the sec- or the first shot. I have control over it a little bit or a lot.

That’s a lot better.

Now I have just control. I’ll be able to tie a fishing line. [laughter]

You have to report back to your doctor, Troy. Oh, yeah. My My primary physician, he said you you you call my office when you get back in town. He says, “I want to know how this went.” And he said, “I’ve got plenty other plenty of people I could recommend to go down there.” But wow. I thought unreal.

Wow.

Oh my gosh. Yeah.

Amazing. [clears throat] Thanks, Doc. [laughter]

Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

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Frequently Asked Questions

Perispinal etanercept is a method of targeting detrimental neuroinflammation using etanercept, a special anti-inflammatory drug, delivered utilizing a novel, non-invasive injection method.

Perispinal etanercept is NOT experimental. Perispinal etanercept has been used to treat more than 5,000 chronic stroke patients since 2010 at the Institute of Neurological Recovery.

Perispinal etanercept is NOT a spinal injection. The small needle utilized is much too short to reach the spinal canal or the epidural space.

No, it is not too late. Neuroinflammation can last for years, or even decades, after brain injury. Life-changing neurological improvements following perispinal etanercept treatment performed weeks, months, years, or even decades after stroke or brain injury are not uncommon.

Referrals are not required. The Institute of Neurological Recovery has received, and welcomes, referrals from neurologists, speech pathologists, physical therapists, occupational therapists, primary care physicians, online stroke groups, and, of course, patients and their family members.

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