Stroke Recovery: Improved Spasticity & Numbness after PSE Treatment at INR

About This Video

Watch a patient who suffered a stroke in January 2025 share their symptoms and describe the changes they experienced immediately following Perispinal Etanercept (PSE) treatment administered by Danielle Ucci, PA-C at the Institute of Neurological Recovery (INR).

Patient-Reported Changes Featured in This Video

  • Reduced Tightness & Spasticity: The patient notes that facial pulling sensations felt lessened and observes that their toes, which previously curled, felt flat and more comfortable. They also report less tightness in the knee.
  • Sensation Returning to Numb Areas: The patient experiences improved sensation on the right side of their body, noting specific returning sensation in their fingers and hand where there was previous numbness.
  • Decreased Joint Discomfort: The patient reports that back discomfort improved while sitting and that their hip, which had been bothering them earlier, was no longer causing discomfort.
  • Improved Energy & Brain Fog: Despite typically experiencing fatigue within an hour, the patient reports feeling more energetic, less tired, and experiencing greater mental clarity (“brain fog” lifting).
  • Speech Ease & Word Finding: The patient and observers note a smoother flow in conversation, with fewer struggles to find words and express thoughts clearly.
Read Video Transcript

*Transcription generated by YouTube

So, when was your stroke? January the 7th,

  1. What kind of difficulties has it caused for you besides walking and talking? Just about anything. the right side, my leg and my arm and my mouth. As you can tell, it come numb. It It draws me crazy and I’m more emotal than it used to be. I’m tired all the time. I I have a the the the brain fog. It’s um where I can think of everything that I’m trying to say, but I can’t make it come out. And that’s extremely frustrating.

that it didn’t feel like it’s pulling very much. Does it look the same? Yeah, it looks the exact same. Oh, well then that’s different because I felt like this, right? It was like this all the time. Mhm. And I don’t feel that right now.

My toes feel good. They’re flat.

That’s always driven me crazy. But my toes will be like that. And they feel flat. That feels better. Good for sure.

That feels better. That’s good. The more I’m sitting here talking to y’all, the better my back and everything is feeling.

Yeah, I can feel I can feel this knee. I can feel this knee before. It feels It [clears throat] It doesn’t feel as tight.

I can feel that. And normally I’m I’m feeling really tired by now. I told y’all I don’t don’t usually get them by more than an hour and then I start going downhill. But I feel better. I can feel it in my head. I feel like I have more energy. Yeah. More clarity. Yeah. That bothering your hip at all? Cuz I know your hips’s been bothering you since you’ve been here. No, it No, it’s not bothering me at all. Hey,

this this one number four. All of that was numb. Yeah, this this part this part is fun. I can feel that much. Is this my eyes open? Yeah, your eyes are open. Your eyes are totally fine. [laughter]

I feel better on the regular talking. You don’t seem like you’re struggling to find the words quite as much, you know. Mhm. And yeah, I was I was more worried about people understanding me. And if people can understand me, then I then I can talk better. [laughter]

Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

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Frequently Asked Questions

Perispinal etanercept is a method of targeting detrimental neuroinflammation using etanercept, a special anti-inflammatory drug, delivered utilizing a novel, non-invasive injection method.

Perispinal etanercept is NOT experimental. Perispinal etanercept has been used to treat more than 5,000 chronic stroke patients since 2010 at the Institute of Neurological Recovery.

Perispinal etanercept is NOT a spinal injection. The small needle utilized is much too short to reach the spinal canal or the epidural space.

No, it is not too late. Neuroinflammation can last for years, or even decades, after brain injury. Life-changing neurological improvements following perispinal etanercept treatment performed weeks, months, years, or even decades after stroke or brain injury are not uncommon.

Referrals are not required. The Institute of Neurological Recovery has received, and welcomes, referrals from neurologists, speech pathologists, physical therapists, occupational therapists, primary care physicians, online stroke groups, and, of course, patients and their family members.

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