Stroke Recovery: Improved Spasticity & Speech after PSE Treatment by Edward Tobinick, M.D.

About This Video

A stroke survivor who suffered a stroke in December 2025 shares her initial observations immediately following Perispinal Etanercept (PSE) treatment at the Institute of Neurological Recovery.

The video captures real-time updates recorded just 22 minutes after the procedure, highlighting patient-reported changes in limb temperature, facial expression, speech fluency, and mental clarity.

Patient-Reported Changes Featured in This Video

  • Temperature Regulation & Reduced Numbness: Prior to treatment, the patient noted that her leg and hand felt frozen “like ice.” Post-treatment, she describes a warming sensation returning to her affected extremities alongside a reduction in numbness.
  • Neck Mobility & Facial Expression: The patient reports a decrease in neck stiffness and demonstrates a fuller, more symmetrical smile.
  • Speech Fluency & Counting: Before the procedure, counting backward was hesitant and difficult. Post-treatment, both the patient and her family note clearer, more articulate speech and increased vocal confidence.
  • Improved Cognition & Brain Fog: The patient and her loved ones highlight an immediate lifting of “brain fog,” describing her as more alert, confident, and sitting with better posture.
Read Video Transcript

*Transcript generated by YouTube

When did you have your stroke? December 4th, uh 2 2025. I want to say that I’m really blessed because my doctor said that my husband the survival rate it was 15 I say 20% chance, but I didn’t survive. And then I’m look at me now. What kind of difficulties has the stroke caused for you? Um I just have uh the numbness I say numbness in the hands and the face. I say uh numbness in the leg. Um the same it’s just cold. Your speech was affected. Yes, yes, yes. Can you count from 1 to 10? Yeah, 1 2 3 4 5 6 7 8 9 10. What about backwards from 10 to 1? Um say 1

10 9 8 6 10 9 8 7 6 5 4 3 2

I’m speaking clearly. I feel better. Yeah, it’s feeling like it’s used to feel like ice, but it’s warming up. I gave a lot of anxiety worrying about it, but it was easy.

My neck is I don’t feel the stiff. [snorts]

[laughter] Does it seem like she looks different? Yes.

Yes. [gasps]

I’m smiling.

It’s back. Thank [snorts] you. Oh, thank you, Jesus. [snorts]

Yes. Yes. Yes. Is it better? Yes. Yes, because it’s No. want to take anymore? I don’t need more.

I am blessed. I am saved, plus and blessed. Yes. I’m feeling good.

It seems like she’s more confident or she got her confidence back. I know her speech is seems like it’s a little better. As far as her speaking is a little better.

It’s awakening. Yeah. The brain fog is gone. Yeah. The Yeah. Yeah.

It’s 22 minutes since the injection. Do you feel a little better? A lot better. A lot. And my hand is coming back. Seems that I’m sitting up more. [clears throat] I can feel it me coming back. Ooh. Yeah. Yeah, it’s

Glory, hallelujah. Thank you. Thank you. Thank you, guys. It’s a miracle. [clears throat] Thank [snorts] you. You’re very welcome. Thank you.

Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use

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Frequently Asked Questions

Perispinal etanercept is a method of targeting detrimental neuroinflammation using etanercept, a special anti-inflammatory drug, delivered utilizing a novel, non-invasive injection method.

Perispinal etanercept is NOT experimental. Perispinal etanercept has been used to treat more than 5,000 chronic stroke patients since 2010 at the Institute of Neurological Recovery.

Perispinal etanercept is NOT a spinal injection. The small needle utilized is much too short to reach the spinal canal or the epidural space.

No, it is not too late. Neuroinflammation can last for years, or even decades, after brain injury. Life-changing neurological improvements following perispinal etanercept treatment performed weeks, months, years, or even decades after stroke or brain injury are not uncommon.

Referrals are not required. The Institute of Neurological Recovery has received, and welcomes, referrals from neurologists, speech pathologists, physical therapists, occupational therapists, primary care physicians, online stroke groups, and, of course, patients and their family members.

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